A Hellenistic city on the Orontes River, founded around 300 BC by one of Alexander the Great's generals and, by the first century, the Roman Empire's third-largest city after Rome and Alexandria. It is where believers are first called ‘Christians’ (Acts 11:26, not yet on these pages), and where the mixed Jewish-and-Gentile congregation that sends Paul and Barnabas out on their first journey is based — which makes it, not Jerusalem, this chapter's real point of origin: the dispute over circumcision (v1) breaks out here, the delegation travels FROM here TO Jerusalem, and the decree travels back to settle exactly this congregation's own quarrel (v30). Distinguished on these pages, when needed, from the smaller Pisidian Antioch of Paul's first journey (Acts 13:14, not yet on these pages) — two different cities founded by the same dynasty and carrying the same name.